Drupal on a stick was tested on Windows XP and should probably run under Windows Vista without a problem, but check out the link for WOS Portable if you have Vista and can't get it to work.
From the WOS Portable site:
"WOS stands for the three letter abbreviation Webserver On Stick and makes it possible, to run a webserver based on Apache, MySQL and PHP from an USB Stick or any other writable media (harddrive, flash cards etc.) without installation under Windows (98 to Vista)."
Comments
WOS on the go
WOS Portable is great. It allows you to run a web server from a USB stick and is compatible with Windows Vista. It offers all the functionality of a web server without taking up any excess space on your machine. You have access to a number of CMS with this system including Drupal and other useful software like PHPMyAdmin. Great for someone on the go!